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CURRENT ISSUE
February, 2022

No. 107 (2)

2020 Impact Factor: 9.941 Submission > Acceptance: 80 days
ARTICLES IN THREE SENTENCES
Article

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity

Hematopoietic stem cells (HSC) maintain blood homeostasis and show an age-related decline in overall function. This study characterized age-related changes in human and murine HSC. The data reported support the possibility of rejuvenating the function of aged human HSC by inhibiting the age-related increase in Cdc42 activity.

Amanda Amoah et al.

Article

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector

Twenty-five percent of patients with Diamond-Blackfan anemia (DBA) have mutations in a gene encoding ribosomal protein S19 (RPS19). The authors of this study developed a single gene, self-inactivating lentiviral vector containing human RPS19 cDNA. It was used for the successful treatment of Rps19-deficient DBA in a mouse model.

Yang Liu et al.

Article

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

APR-246 is a new therapeutic agent that targets mutated p53 proteins in acute myeloid leukemia (AML) and myelodysplastic syndromes. APR-246 can also induce p53-independent cell death in cancer. The authors of this study demonstrated that cell death promoted by APR-246 in AML is due to induction of ferroptosis, which may represent a new therapeutic target in AML.

Rudy Birsen et al.

Article

Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis

The diagnosis of angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma with T follicular helper phenotype is challenging. This study showed that RHOA Gly17Val mutation analysis is valuable in the early detection of these disorders.

Rachel Dobson et al.

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