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2020 Impact Factor: 9.941Submission > Acceptance: 80 days
Hematopoietic stem cells (HSC) maintain blood homeostasis and show an age-related decline in overall function. This study characterized age-related changes in human and murine HSC. The data reported support the possibility of rejuvenating the function of aged human HSC by inhibiting the age-related increase in Cdc42 activity.
Twenty-five percent of patients with Diamond-Blackfan anemia (DBA) have mutations in a gene encoding ribosomal protein S19 (RPS19). The authors of this study developed a single gene, self-inactivating lentiviral vector containing human RPS19 cDNA. It was used for the successful treatment of Rps19-deficient DBA in a mouse model.
APR-246 is a new therapeutic agent that targets mutated p53 proteins in acute myeloid leukemia (AML) and myelodysplastic syndromes. APR-246 can also induce p53-independent cell death in cancer. The authors of this study demonstrated that cell death promoted by APR-246 in AML is due to induction of ferroptosis, which may represent a new therapeutic target in AML.
The diagnosis of angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma with T follicular helper phenotype is challenging. This study showed that RHOA Gly17Val mutation analysis is valuable in the early detection of these disorders.