CURRENT ISSUE
February, 2022
No. 107 (2)
BEESWAX - White - 16 oz pure USA beeswax slabs - buy more than olisting unless Running box or
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Neodymium
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Elma
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India
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Ultradecals
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Make:
OPERATORS Publication:
2019
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Media
Condition:
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Paper
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Year USER other Running OWNER
Country
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United
2020 Impact Factor: 9.941
Submission > Acceptance: 80 days
EDITOR'S PICKS
ARTICLES IN THREE SENTENCES
Article
Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity
Hematopoietic stem cells (HSC) maintain blood homeostasis and show an age-related decline in overall function. This study characterized age-related changes in human and murine HSC. The data reported support the possibility of rejuvenating the function of aged human HSC by inhibiting the age-related increase in Cdc42 activity.
Article
Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector
Twenty-five percent of patients with Diamond-Blackfan anemia (DBA) have mutations in a gene encoding ribosomal protein S19 (RPS19). The authors of this study developed a single gene, self-inactivating lentiviral vector containing human RPS19 cDNA. It was used for the successful treatment of Rps19-deficient DBA in a mouse model.
Article
APR-246 induces early cell death by ferroptosis in acute myeloid leukemia
APR-246 is a new therapeutic agent that targets mutated p53 proteins in acute myeloid leukemia (AML) and myelodysplastic syndromes. APR-246 can also induce p53-independent cell death in cancer. The authors of this study demonstrated that cell death promoted by APR-246 in AML is due to induction of ferroptosis, which may represent a new therapeutic target in AML.
Article
Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis
The diagnosis of angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma with T follicular helper phenotype is challenging. This study showed that RHOA Gly17Val mutation analysis is valuable in the early detection of these disorders.
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